Antioxidants (Basel). 2020 Sep 15 ;9(9). Epub 2020 Sep 15. PMID: 32942738
Supplementation Effect of a Combination of Olive (L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome.
BACKGROUND: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS).METHODS: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined.RESULTS: Significant reductions (