Am J Phys Med Rehabil. 2020 Nov 14. Epub 2020 Nov 14. PMID: 33229887
The effect of alpha lipoic acid on the recovery of sciatic nerve injury in rats: a prospective randomized controlled trial.
OBJECTIVE: Investigating regenerative effects of ALA on recovery of SNCI in rats.DESIGN: Randomized, experimental, and sham-controlled study. Sciatic nerves of 28 rats in 4 groups were traumatized for 60 seconds. G1; sham-operated + saline, G2; SNCI + saline, G3; SNCI + ALA 50 mg/kg/day, G4; SNCI + ALA 100 mg/kg/day. SFI values were measured on day 0, 1, 7, 14, 21, and 28. Sciatic nerve stimulation threshold values (STV) were recorded on day 1, 14, and 28. Endpoint histopathologic evaluation was conducted.RESULTS: Mean SFI value of G2 but not G3/G4 on day 7 was significantly lower than day 0 (p=0.035, p=0.447/p=0.800). Mean SFI value of G2 but not G3/G4 increased significantly between day 7 and 14 (p=0.035, p=0.447/p=0.438). Day 14 mean sciatic nerve STV of G3/G4 but not G2 were decreased significantly compared to day 1 (p=0.022/p=0.022, p=0.933). Mean sciatic nerve STV of G3/G4 on day 14 were similar to day 0 (p=0.106/p=0.418). Regeneration in muscle and nerve connective tissues, and nerve structures were observed in G3/G4. Inflammation in muscle and nerve tissues of G4 was suppressed down to similar levels of G1. Myelinated nerve fibers were less degenerated in G3/G4.CONCLUSION: ALA has the potential to accelerate the process of nerve healing in the context of SNCI in rats.