In vitro anti-parasitic activity of Pelargonium X. asperum essential oil against Toxoplasma gondii.

PMID: 

Front Cell Dev Biol. 2021 ;9:616340. Epub 2021 Feb 18. PMID: 33681197

Abstract Title: 

Anti-parasitic Activity ofEssential Oil Against.

Abstract: 

Toxoplasmosis is a global zoonotic disease, and one-third of the human population is chronically infected by. Due to the limited effectiveness and prominent side effects of the existing drugs, there is a dire need for the discovery of new therapeutic options in the treatment of toxoplasmosis. In this study, five essential oils (EO) were screened for their anti-parasitic activity against. The cytotoxicity of essential oils was evaluated using the MTT assay on human foreskin fibroblast cells. The CCvalues ofEO,EO,EO,EO, andEO were found to be 22.74, 7.25, 15.01, 6.26, and 4.77 mg/mL, respectively. OnlyEO exhibited anti-parasitic activity, and inhibited the growth ofin a dose-dependent manner. In addition, treatment withEO, was found to reduce the volume oftachyzoites and make their membrane surfaces rough. These results showed thatEO was able to inhibit the growth ofby reducing invasion, which may be due to its detrimental effect on the ability of tachyzoites to move. These findings suggest thatEO could be a potential anti-drug, which may facilitate the development of new and effective treatments against toxoplasmosis.

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