J Complement Integr Med. 2021 May 11. Epub 2021 May 11. PMID: 33977689
Ameliorative effect of Kolaviron, an extract ofseeds, on induced hypertension.
OBJECTIVES: Early diagnosis and management of known cardiovascular disease risk attributes such as hypertension lessens morbidity and mortality as well as increase quality of life of patients. This present study was modelled to investigate the ameliorative effect of Kolaviron, an extract ofHeckel seeds, in ethanol- and sucrose-induced hypertension.METHODS: Test animals were divided into six groups of six animals each for each hypertensive model. Animals were treated daily with distilled water (10 ml/kg); 35% ethanol (3 g/kg) or sucrose (5-7%); Kolaviron (50, 100 and 200 mg/kg) separately plus ethanol or sucrose and Amlodipine (0.14 mg/kg) separately plus ethanol or sucrose for 8 weeks. Systolic, diastolic and mean arterial pressures were determined using non-invasive BP system after 8 weeks. Blood was obtained for the assessment of biochemical parameters, lipid profile and antioxidant indices. Vital organs were collected for approximation of tissue antioxidant levels.RESULTS: Results show that Kolaviron at various doses and Amlodipine significantly reduced (p