Front Chem. 2020 ;8:581. Epub 2020 Jul 22. PMID: 32850623
Mechanisms of Macrophage Immunomodulatory Activity Induced by a New Polysaccharide Isolated From(Pers.) Fries.
Bladder cancer is one of the most malignant tumors closely associated with macrophage immune dysfunction. The Chinese medicine polyporus has shown excellent efficacy in treating bladder cancer, with minimal side effects. However, its material basis and mechanism of action remain unclear. A new water-soluble polysaccharide (HPP) with strong immunomodulatory activity was isolated from the fungus(Pers.) Fries. HPP had an average molecular weight of 6.88 kDa and was composed mainly of an