J Diabetes Metab Disord. 2020 Dec ;19(2):1303-1310. Epub 2020 Oct 3. PMID: 33553029
Mormodica charantia L. fruit and Genistein ameliorates type 2 diabetes in rats by preventing lipid accumulation, insulin resistance and enhancing beta cell function.
Purpose: The present study was aimed at evaluating the role offruit and Genistein on beta cell, insulin resistance/sensitivity and lipid profile in type 2 diabetic rats.Methods: Thirty-five (35) albino rats were divided into seven (7) groups of 5 rats each comprising of five (5) non-diabetic and thirty (30) diabetic rats. Groups 1 and 2 served as the normal control and diabetic control groups respectively and received distill water, groups 3 and 4 receivedat 250 mg/kg and 500 mg/kg respectivelyGroups 5 and 6 received Genistein at 10 mg/kg and 20 mg/kg respectively while group 7 received Metformin at 500 mg/kg the experiment lasted for four weeks. All the rats were euthanized at the end of the fourth week.Results: Lipid profile, glucose and insulin levels were determined from the analysis of serum parameters and the histology of the pancreas. A significant reduction (