Afr Health Sci. 2020 Sep ;20(3):1382-1396. PMID: 33402987
Nephroprotective effect of methanol extract ofleaves on acute kidney injury induced by ischemia-reperfusion in rats.
Background: is known to exhibit protection against oxidative damage due to its rich content of compounds with antioxidant activity. This study investigated the protective effect of the methanol extract of(MO) in a rat model of renal ischemia-reperfusion (IR) injury.Methods: Forty two wistar rats were randomly assigned to six groups of seven rats each, as follows: A, control group; B, sham-operated group; C, IR group; D, IR + low dose (200 mg/kg) MO; E, IR + high dose (400 mg/kg) MO and F, IR + Vitamin C (200 mg/kg). Unilateral ischaemia was induced by occluding the left renal artery for 45 minutes followed by reperfusion up to 24 hours.Results: significantly (p