Two new compounds with Nrf2 inducing activity from Glycyrrhiza uralensis.


Nat Prod Res. 2020 Jan 30:1-8. Epub 2020 Jan 30. PMID: 31999210

Abstract Title: 

Two new compounds with Nrf2 inducing activity from.


Two new compounds including a new 3-arylcoumarin liquiritcoumarin (), and a new flavonoid glycoside crotoliquiritin (), together with twelve known compounds (-) were isolated from the radix and rhizome of. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All of the compounds were evaluated for the cytotoxic activities. Only compoundshowed moderate effects with ICof 11.46 μM for A549 cells and ICof 7.38 μM for NCI-H292 cells. Compoundsandwere demonstrated to be Nrf2 pathway activators by using a stable antioxidant response element (ARE)-dependent reporter gene assay together with immunoblot and immunofluorescence analysis.

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